Scientific References

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MECHANISM OF ACTION (MOA) REFERENCES

Molecular Pathways: Trafficking of Metabolic Resources in the Tumor Microenvironment  Clinical Cancer Research (2015) vol 21, is. 4

Cancer Cell Metabolism: Warburg and Beyond Cell. 2008; 134:5

Cancer as a Metabolic Disease. Nutr Metab. 2010;7:7  

Q&A: Cancer: Clues from cell metabolism. Nature Research. 2010; 465:7298

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation. Science. 2009; 324:5930

The Warburg Effect: How Does it Benefit Cancer Cells? Trends Biochem Sci. 2016; 41:3

Metabolic requirements for cancer cell proliferation. Cancer & Metabolism. 2016; 4:16

Metabolism shapes the tumor microenvironment. ScienceDirect


MUCIN ROLE IN CANCER SURVIVAL

Molecular Pathways: Trafficking of Metabolic Resources in the Tumor Microenvironment. Clinical Cancer Research (2015) vol 21, is. 4

Muc-1 Core Protein Is Expressed on Multiple Myeloma Cells and Is Induced by Dexamethasone. Blood; 93: No 4

MUC1 activates JNK1 and inhibits apoptosis under genotoxic stress. Biochemical and Biophysical Research Communications; 440:1

MUC1 IS A POTENTIAL TARGET FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA STEM CELLS. Cancer Res. 2013; 73:17

MUC1: a multifaceted oncoprotein with a key role in cancer progression. Trends in Molecular Medicine. 2014;20:6

Mucins in cancer: function, prognosis and therapy. Nature Reviews Cancer. 2009; 9

Human MUC1 Carcinoma Antigen Regulates Intracellular Oxidant Levels and the Apoptotic Response to Oxidative Stress.  JBC 2003; 278:37

Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells. Oncogene 2010; 29:20

MUC1-C Stabilizes MCL-1 in the Oxidative Stress Response of Triple-Negative Breast Cancer Cells to BCL-2 Inhibitors. Scientific Reports 2016 May 24; 6:26643

Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2


AMINO ACID UPTAKE BY CANCER CELLS

Nonessential amino acid metabolism in breast cancer. Adv Biological Regulation. 2016;62

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. ScienceDirect

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism. eLife 2016;5

Targeting amino acid metabolism for cancer therapy. ScienceDirect

Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime? Seminar in Cancer Biology 2005; 15:4

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. Developmental Cell 2016; 36: 5

Targeting amino acid metabolism for cancer therapy. Drug Discovery Today 2017; 22:5

Amino Acid Transporters in Cancer and Their Relevance to “Glutamine Addiction”: Novel Targets for the Design of a New Class of Anticancer Drugs. Cancer Research 2015; 75:9


CELLULAR PROCESSING OF D-AMINO ACIDS

The ribosome can discriminate the chirality of amino acids within its peptidyl-transferase center. PNAS 2015;112:19

Aminoacyl-tRNA synthetases and tumorigenesis: more than housekeeping. Nature Reviews Cancer 2011; 11

Kinetics of Ribosome-Catalyzed Polymerization Using Artificial Aminoacyl-tRNA Substrates Clarifies Inefficiencies and Improvements. ACS Chem. Biol., 2015;10: 10

Human D-Tyr-tRNATyr deacylase contributes to the resistance of the cell to D-amino acids. Biochem. J. 2009; 417


RAPAMYCIN AND CANCER CELL METABOLISM

Molecular Pathways: Trafficking of Metabolic Resources in the Tumor Microenvironment.  Clinical Cancer Research (2015) vol 21, is. 4

Abstract 5286: Expression of cancer type amino acid transporter LAT1 is a prognosis prediction factor in breast carcinoma: comparison between triple-negative and non-triple-negative types. Cancer Research. 2015;75:15

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science, 2008; 320

Amino Acid Transporters in Cancer and Their Relevance to “Glutamine Addiction”: Novel Targets for the Design of a New Class of Anticancer Drugs. Cancer Res; 75:9

Clues from cell metabolism. Nature 2010; 465

Amino Acid Transporters in Cancer and Their Relevance to “Glutamine Addiction”: Novel Targets for the Design of a New Class of Anticancer Drugs. Cancer Research 2015; 75:9

Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth. Cancer Research


PHENYTOIN AND ROLE OF LIPIDS IN CANCER METABOLISM

The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Molecular Cancer. 2015;14:13

Decreased total antioxidant capacity and elevated lipid hydroperoxide concentrations in sera of epileptic patients receiving phenytoin. Life Sciences. 1997;61:4

Pancreatic cancer cell growth requires lipids released by tumor-induced stroma autophagy.  Cancer Research. 2017; 77:13

Lipid metabolic reprogramming in cancer cells. Oncogenesis, 2016; 5

The Tumor Microenvironment Modulates Choline and Lipid Metabolism. Front Oncol. 2016;6:262

Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment. ScienceDirect

The Tumor Microenvironment Modulates Choline and Lipid Metabolism. Front. Oncol.,2016; 6

The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis.


METHOXSALEN AND MELANOCYTES AND ROLE OF LIPIDS IN CANCER METABOLISM

Melanocytes as Instigators and Victims of Oxidative Stress. ScienceDirect

What are melanocytes really doing all day long…? : from the ViewPoint of a keratinocyte: Melanocytes – cells with a secret identity and incomparable abilities. Scientific Reports. 2016;6:26643

Generation of hydrogen peroxide in the melanin biosynthesis pathway. Biochimica et Biophysica Acta (BBA) – Proteins and Proteomics 2009; 1794: 7


CIRCULATING TUMOR CELLS

Circulating tumor cells correlate with patterns of recurrence in patients with hormone-sensitive prostate cancer. OncoTargets and Therapy 2017; 10: 3811-3815.

Circulating tumor cells and their role in prostate cancer. Asian Journal of Andrology 2017 Aug 22

Improving circulating tumor cells enumeration and characterization to predict outcome in first-line chemotherapy mCRPC patients. Oncotarget 2017 Aug 15; 8 (33) : 54708-54721.